Dendrimer-Conjugated nSMase2 Inhibitor Reduces Tau Propagation in Mice

• Main Authors: Carolyn Tallon (Author), Benjamin J. Bell (Author), Anjali Sharma (Author), Arindom Pal (Author), Medhinee M. Malvankar (Author), Ajit G. Thomas (Author), Seung-Wan Yoo (Author), Kristen R. Hollinger (Author), Kaleem Coleman (Author), Elizabeth L. Wilkinson (Author), Sujatha Kannan (Author), Norman J. Haughey (Author), Rangaramanujam M. Kannan (Author), Rana Rais (Author), Barbara S. Slusher (Author)
• Format: Book
• Published: MDPI AG, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Alzheimer's disease (AD) is characterized by the progressive accumulation of amyloid-β and hyperphosphorylated tau (pTau), which can spread throughout the brain via extracellular vesicles (EVs). Membrane ceramide enrichment regulated by the enzyme neutral sphingomyelinase 2 (nSMase2) is a criti...