DsbA-L activates TGF-β1/SMAD3 signaling and M2 macrophage polarization by stimulating AKT1 and NLRP3 to promote pulmonary fibrosis

DsbA-L activates TGF-β1/SMAD3 signaling and M2 macrophage polarization by stimulating AKT1 and NLRP3 to promote pulmonary fibrosis

Abstract Background Pulmonary fibrosis (PF) is a progressive and difficult-to-heal lung disease that poses a significant threat to human life and health. This study aimed to investigate the potential pathological mechanisms of PF and to identify new avenues for the treatment of PF. Methods Clinical...

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Main Authors: Juan Wang (Author), Zhenkun Xia (Author), Bei Qing (Author), Ying Chen (Author), Linguo Gu (Author), Hongzuo Chen (Author), Zhenglian Ge (Author), Yunchang Yuan (Author)
Format: Book
Published: BMC, 2024-11-01T00:00:00Z.
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