Insights on Cancer Cell Inhibition, Subcellular Activities, and Kinase Profile of Phenylacetamides Pending 1H-Imidazol-5-One Variants

• Main Authors: Maan T. Khayat (Author), Abdelsattar M. Omar (Author), Farid Ahmed (Author), Mohammad I. Khan (Author), Sara M. Ibrahim (Author), Yosra A. Muhammad (Author), Azizah M. Malebari (Author), Thikryat Neamatallah (Author), Moustafa E. El-Araby (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Structural changes of small-molecule drugs may bring interesting biological properties, especially in the field of kinase inhibitors. We sought to study tirbanibulin, a first-in-class dual Src kinase (non-ATP competitive)/tubulin inhibitor because there was not enough reporting about its structure-a...