Pharmacokinetic and pharmacodynamic study of triptolide-loaded liposome hydrogel patch under microneedles on rats with collagen-induced arthritis

Triptolide (TP), a major active component of Tripterygium wilfordii Hook.F. (TWHF), is used to treat rheumatoid arthritis (RA). However, it has a narrow therapeutic window due to its serious toxicities. To increase the therapeutic index, a new triptolide-loaded transdermal delivery system, named tri...

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Main Authors: Gui Chen (Author), Baohua Hao (Author), Dahong Ju (Author), Meijie Liu (Author), Hongyan Zhao (Author), Zhongping Du (Author), Jizi Xia (Author)
Format: Book
Published: Elsevier, 2015-11-01T00:00:00Z.
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