Integrated high-throughput analysis identifies super enhancers associated with chemoresistance in SCLC

• Main Authors: Jiarong Bao (Author), Man Li (Author), Shumei Liang (Author), Yunchu Yang (Author), Jingfang Wu (Author), Qingqing Zou (Author), Shun Fang (Author), Size Chen (Author), Linlang Guo (Author)
• Format: Book
• Published: BMC, 2019-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Chemoresistance is a primary clinical challenge for the management of small cell lung cancer. Additionally, transcriptional regulation by super enhancer (SE) has an important role in tumor evolution. The functions of SEs, a key class of noncoding DNA cis-regulatory elements, have...