T lymphocytes from chagasic patients are activated but lack proliferative capacity and down-regulate CD28 and CD3ζ.

• Main Authors: Nicolás A Giraldo (Author), Natalia I Bolaños (Author), Adriana Cuellar (Author), Nubia Roa (Author), Zulma Cucunubá (Author), Fernando Rosas (Author), Víctor Velasco (Author), Concepción J Puerta (Author), John M González (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: Chronic persistent infections have been associated with T lymphocytes functional impairment. The aim of this study was to compare the activation status, the proliferative potential and the expression of CD28 and CD3ζ chain on T lymphocytes between chronic chagasic patients and uninfected...