The Antimicrobial Effects of Colistin Encapsulated in Chelating Complex Micelles for the Treatment of Multi-Drug-Resistant Gram-Negative Bacteria: A Pharmacokinetic Study

• Main Authors: Wei-Chuan Liao (Author), Chau-Hui Wang (Author), Tzu-Hui Sun (Author), Yu-Cheng Su (Author), Chia-Hung Chen (Author), Wen-Teng Chang (Author), Po-Lin Chen (Author), Yow-Ling Shiue (Author)
• Format: Book
• Published: MDPI AG, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<i>Background:</i> Infections caused by multi-drug-resistant Gram-negative bacteria (MDR-GNB) are an emerging problem globally. Colistin is the last-sort antibiotic for MDR-GNB, but its toxicity limits its clinical use. We aimed to test the efficacy of colistin-loaded micelles (CCM-CL) a...