Volatile Composition, Antimicrobial and free radical scavenging activities of essential oil and total extract of Helichrysum leucocephalum Boiss.
<p>The present study investigated the composition of essential oil and evaluation antimicrobial and antioxidant of the ethanolic extract of the aerial parts of <em>Helichrysum leucocephalum</em>. Gas chromatography/mass spectrometry (GC/MS) revealed the presence of 43 compounds whi...
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| Váldodahkkit: | , , |
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| Materiálatiipa: | Girji |
| Almmustuhtton: |
Shiraz University of Medical Sciences,
2017-09-01T00:00:00Z.
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| Čoahkkáigeassu: | <p>The present study investigated the composition of essential oil and evaluation antimicrobial and antioxidant of the ethanolic extract of the aerial parts of <em>Helichrysum leucocephalum</em>. Gas chromatography/mass spectrometry (GC/MS) revealed the presence of 43 compounds which represents 96.8% of the total oil. Carvacrol (20.36%), acetophenone (11.17%) and azulene (7.09%) were identified as the main principal components of the essential oil. <em>H. leucocephalum</em> ethanolic extract exhibited a high phenol content (114.13±0.89 mg gallic acid equivalent (GAE)/g of dry plant) while total flavonoid content was found to be 43.26±0.70 mg quercetin equivalent (QE)/g of dry plant). In order to evaluate antioxidant efficacy of the essential oil and ethanolic extract, DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical scavenging and ferric reducing antioxidant power.<em> (</em>FRAP)<em> assays were conducted. The ethanolic extract demonstrated significant </em>DPPH<em> free radical Inhibitory activity</em><em> </em>(IC<sub>50 </sub>= 61.35±0.07 µg/mL) and ferric reducing ability (IC<sub>50</sub>= 113.43±0.58 µg/mL) while the essential oil declared a weak antioxidant properties. Antimicrobial screening revealed higher degree of inhibition for essential oil of the aerial parts of <em>H. leucocephalum</em> against <em>Staphylococcus aureus</em> and <em>Escherichia coli </em>both with MIC value, 16 µg/mL. Additionally the essential oil of <em>H. leucocephalum</em> exhibited antifungal properties when tested against <em>Candida albicans</em> (MIC<sub>50</sub>, 32 µg/mL). </p> |
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| Fuomášahttimat: | 2423-3722 2423-5652 10.1111/tips.v3i3.151 |