Bruceine a exerts antitumor effect against colon cancer by accumulating ROS and suppressing PI3K/Akt pathway

• Main Authors: Chaozheng Zhang (Author), Yuening Cao (Author), Yi Zuo (Author), Hongbin Cheng (Author), Changqun Liu (Author), Xila Xia (Author), Bo Ren (Author), Yun Deng (Author), Maolin Wang (Author), Jun Lu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Bruceine A (BA), a quassic ester from bruceine javanica, regulates diverse intracellular signal transduction pathways and manifests a variety of biological activities, however, its pharmacological mechanism in treating colon cancer (CC) is unclear. In this study, we investigated the anticancer effec...