Improving the Solubility and Oral Bioavailability of a Novel Aromatic Aldehyde Antisickling Agent (PP10) for the Treatment of Sickle Cell Disease

• Asıl Yazarlar: Tarek A. Ahmed (Yazar), Khalid M. El-Say (Yazar), Fathy I. Abd-Allah (Yazar), Abdelsattar M. Omar (Yazar), Moustafa E. El-Araby (Yazar), Yosra A. Muhammad (Yazar), Piyusha P. Pagare (Yazar), Yan Zhang (Yazar), Khadijah A. Mohmmad (Yazar), Osheiza Abdulmalik (Yazar), Martin K. Safo (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: MDPI AG, 2021-07-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Background: Aromatic aldehydes, with their ability to increase the oxygen affinity of sickle hemoglobin, have become important therapeutic agents for sickle cell disease (SCD). One such compound, voxelotor, was recently approved for SCD treatment. Methyl 6-((2-formyl-3-hydroxyphenoxy)methyl) picolin...