Improving the Solubility and Oral Bioavailability of a Novel Aromatic Aldehyde Antisickling Agent (PP10) for the Treatment of Sickle Cell Disease

• मुख्य लेखकों: Tarek A. Ahmed (लेखक), Khalid M. El-Say (लेखक), Fathy I. Abd-Allah (लेखक), Abdelsattar M. Omar (लेखक), Moustafa E. El-Araby (लेखक), Yosra A. Muhammad (लेखक), Piyusha P. Pagare (लेखक), Yan Zhang (लेखक), Khadijah A. Mohmmad (लेखक), Osheiza Abdulmalik (लेखक), Martin K. Safo (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2021-07-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Background: Aromatic aldehydes, with their ability to increase the oxygen affinity of sickle hemoglobin, have become important therapeutic agents for sickle cell disease (SCD). One such compound, voxelotor, was recently approved for SCD treatment. Methyl 6-((2-formyl-3-hydroxyphenoxy)methyl) picolin...