Improving the Solubility and Oral Bioavailability of a Novel Aromatic Aldehyde Antisickling Agent (PP10) for the Treatment of Sickle Cell Disease

• Main Authors: Tarek A. Ahmed (Author), Khalid M. El-Say (Author), Fathy I. Abd-Allah (Author), Abdelsattar M. Omar (Author), Moustafa E. El-Araby (Author), Yosra A. Muhammad (Author), Piyusha P. Pagare (Author), Yan Zhang (Author), Khadijah A. Mohmmad (Author), Osheiza Abdulmalik (Author), Martin K. Safo (Author)
• Format: Book
• Published: MDPI AG, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Aromatic aldehydes, with their ability to increase the oxygen affinity of sickle hemoglobin, have become important therapeutic agents for sickle cell disease (SCD). One such compound, voxelotor, was recently approved for SCD treatment. Methyl 6-((2-formyl-3-hydroxyphenoxy)methyl) picolin...