Improving the Solubility and Oral Bioavailability of a Novel Aromatic Aldehyde Antisickling Agent (PP10) for the Treatment of Sickle Cell Disease

Improving the Solubility and Oral Bioavailability of a Novel Aromatic Aldehyde Antisickling Agent (PP10) for the Treatment of Sickle Cell Disease

Background: Aromatic aldehydes, with their ability to increase the oxygen affinity of sickle hemoglobin, have become important therapeutic agents for sickle cell disease (SCD). One such compound, voxelotor, was recently approved for SCD treatment. Methyl 6-((2-formyl-3-hydroxyphenoxy)methyl) picolin...

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Main Authors: Tarek A. Ahmed (Author), Khalid M. El-Say (Author), Fathy I. Abd-Allah (Author), Abdelsattar M. Omar (Author), Moustafa E. El-Araby (Author), Yosra A. Muhammad (Author), Piyusha P. Pagare (Author), Yan Zhang (Author), Khadijah A. Mohmmad (Author), Osheiza Abdulmalik (Author), Martin K. Safo (Author)
Format: Book
Published: MDPI AG, 2021-07-01T00:00:00Z.
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3rd Floor Main Library

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