HPV16 E6/E7 promote the translocation and glucose uptake of GLUT1 by PI3K/AKT pathway relieving miR-451 inhibitory effect on CAB39 in lung cancer cells

• Main Authors: Hong-Miao Wang (Author), Ying-Jie Lu (Author), Ling He (Author), Na-Jin Gu (Author), Shi-Yu Wang (Author), Xue-Shan Qiu (Author), En-Hua Wang (Author), Guang-Ping Wu (Author)
• Format: Book
• Published: SAGE Publishing, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: HPV16 E6/E7 proteins are the main oncogenes and only long-term persistent infection causes lung cancer. Our previous studies have shown that HPV16 E6/E7 protein up-regulates the expression of GLUT1 in lung cancer cells. However, whether E6 and E7 protein can promote the glucose uptake of...