Molecular Approaches to the Treatment, Prophylaxis, and Diagnosis of Alzheimer's Disease: Possible Involvement of HRD1, a Novel Molecule Related to Endoplasmic Reticulum Stress, in Alzheimer's Disease

• Main Authors: Masayuki Kaneko (Author), Yasunobu Okuma (Author), Yasuyuki Nomura (Author)
• Format: Bog
• Udgivet: Elsevier, 2012-01-01T00:00:00Z.
• Fag: article
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Endoplasmic reticulum (ER)-associated degradation (ERAD) is a protective mechanism against ER stress in which unfolded proteins accumulated in the ER are selectively transported to the cytosol for degradation by the ubiquitin-proteasome system. We cloned the novel ubiquitin ligase HRD1, which is inv...