High-fat diet reprograms the epigenome of rat spermatozoa and transgenerationally affects metabolism of the offspring

• Главные авторы: Thais de Castro Barbosa (Автор), Lars R. Ingerslev (Автор), Petter S. Alm (Автор), Soetkin Versteyhe (Автор), Julie Massart (Автор), Morten Rasmussen (Автор), Ida Donkin (Автор), Rasmus Sjögren (Автор), Jonathan M. Mudry (Автор), Laurène Vetterli (Автор), Shashank Gupta (Автор), Anna Krook (Автор), Juleen R. Zierath (Автор), Romain Barrès (Автор)
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• Опубликовано: Elsevier, 2016-03-01T00:00:00Z.
• Предметы: article
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Objectives: Chronic and high consumption of fat constitutes an environmental stress that leads to metabolic diseases. We hypothesized that high-fat diet (HFD) transgenerationally remodels the epigenome of spermatozoa and metabolism of the offspring. Methods: F0-male rats fed either HFD or chow diet...