High-fat diet reprograms the epigenome of rat spermatozoa and transgenerationally affects metabolism of the offspring

• Main Authors: Thais de Castro Barbosa (Author), Lars R. Ingerslev (Author), Petter S. Alm (Author), Soetkin Versteyhe (Author), Julie Massart (Author), Morten Rasmussen (Author), Ida Donkin (Author), Rasmus Sjögren (Author), Jonathan M. Mudry (Author), Laurène Vetterli (Author), Shashank Gupta (Author), Anna Krook (Author), Juleen R. Zierath (Author), Romain Barrès (Author)
• Format: Book
• Published: Elsevier, 2016-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: Chronic and high consumption of fat constitutes an environmental stress that leads to metabolic diseases. We hypothesized that high-fat diet (HFD) transgenerationally remodels the epigenome of spermatozoa and metabolism of the offspring. Methods: F0-male rats fed either HFD or chow diet...