Population pharmacokinetics and dose evaluations of linezolid in the treatment of multidrug-resistant tuberculosis

• Main Authors: Haoyue Zhang (Author), Yuying He (Author), Lina Davies Forsman (Author), Jakob Paues (Author), Jim Werngren (Author), Katarina Niward (Author), Thomas Schön (Author), Judith Bruchfeld (Author), Jan-Willem Alffenaar (Author), Yi Hu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: The pharmacokinetic/pharmacodynamics (PK/PD) target derived from the hollow-fiber system model for linezolid for treatment of the multidrug-resistant tuberculosis (MDR-TB) requires clinical validation. Therefore, this study aimed to develop a population PK model for linezolid when admini...