The Comparison Between the Mutated HuIFN-β 27-101 and the Wild Type Interferon β: the Comprehensive In Silico Study to Evaluate the Effect of Mutations on IFN-β

• 主要な著者: Sayed Sharif Balkhi (著者), Zohreh Hojati (著者)
• フォーマット: 図書
• 出版事項: Tabriz University of Medical Sciences, 2019-10-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Purpose: Interferon beta (IFN-β) is used to combat multiple sclerosis (MS) disease. Creating R27T and V101F mutations (mHuIFN-β-27 and mHuIFN-β-101) is one of the tasks performed to improve human interferon beta (HuIFN-β) half-life, function and expression. In this work, the impact of R27T and V101F...