Metabolomics Reveals the Efficacy of Caspase Inhibition for Saikosaponin D-Induced Hepatotoxicity

• Main Authors: Qian-qian Zhang (Author), Wan-qiu Huang (Author), Yi-qiao Gao (Author), Zhao-di Han (Author), Wei Zhang (Author), Zun-jian Zhang (Author), Feng-guo Xu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Saikosaponin d (SSd) is a major hepatoprotective component of saikosaponins derived from Radix Bupleuri, which was also linked to hepatotoxicity. Previous studies have demonstrated that caspases play a key role in SSd-induced liver cell death. Our in vitro and in vivo studies also showed that treatm...