An Entire Process Optimization Strategy for Comprehensive In Vivo Metabolite Profiling of Prucalopride in Rats Based on Ultra-Performance Liquid Chromatography With Q-Exactive Hybrid Quadrupole-Orbitrap High-Resolution Mass Spectrometry

• Hoofdauteurs: Lihua Zuo (Auteur), Liwei Liu (Auteur), Yantao Yang (Auteur), Jie Yang (Auteur), Min Chen (Auteur), Huafeng Zhang (Auteur), Jian Kang (Auteur), Xiaojian Zhang (Auteur), Jiabo Wang (Auteur), Zhi Sun (Auteur)
• Formaat: Boek
• Gepubliceerd in: Frontiers Media S.A., 2021-05-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Prucalopride was widely used for chronic constipation, which is difficult to be adequately relieved by laxatives in adult patients in clinic. Due to the difficulty in metabolite identification, metabolic process of prucalopride had not been investigated in vivo. In this study, an efficient strategy...