Genetic and functional role of TNF-alpha in the development Trypanosoma cruzi infection.

• Main Authors: Cristina Wide Pissetti (Author), Dalmo Correia (Author), Rafael Faria de Oliveira (Author), Maurício Manoel Llaguno (Author), Marly Aparecida Spadotto Balarin (Author), Roseane Lopes Silva-Grecco (Author), Virmondes Rodrigues (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2011-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

TNF-alpha plays an important role in trypanocidal mechanisms and is related to tissue injury. This cytokine has been detected in the heart of human chagasic patients where it is associated with tissue damage. This study investigated whether TNF-alpha levels and the presence of genetic polymorphisms...