Discrimination of polysorbate 20 by high-performance liquid chromatography-charged aerosol detection and characterization for components by expanding compound database and library

• Váldodahkkit: Shi-Qi Wang (Dahkki), Xun Zhao (Dahkki), Li-Jun Zhang (Dahkki), Yue-Mei Zhao (Dahkki), Lei Chen (Dahkki), Jin-Lin Zhang (Dahkki), Bao-Cheng Wang (Dahkki), Sheng Tang (Dahkki), Tom Yuan (Dahkki), Yaozuo Yuan (Dahkki), Mei Zhang (Dahkki), Hian Kee Lee (Dahkki), Hai-Wei Shi (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Elsevier, 2024-05-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Analyzing polysorbate 20 (PS20) composition and the impact of each component on stability and safety is crucial due to formulation variations and individual tolerance. The similar structures and polarities of PS20 components make accurate separation, identification, and quantification challenging. I...