IκB kinase promotes Nrf2 ubiquitination and degradation by phosphorylating cylindromatosis, aggravating oxidative stress injury in obesity-related nephropathy

• Main Authors: Yin-Yin Chen (Author), Han Hong (Author), Yu-Ting Lei (Author), Jia Zou (Author), Yi-Ya Yang (Author), Li-Yu He (Author)
• Formato: Livro
• Publicado em: BMC, 2021-10-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Abstract Background Obesity-related nephropathy (ORN) has become one of the leading causes of end-stage renal disease and has tripled over the past decade. Previous studies have demonstrated that decreased reactive oxygen species production may contribute to improving ORN by ameliorating oxidative s...