Abnormal lipid droplets accumulation induced cognitive deficits in obstructive sleep apnea syndrome mice via JNK/SREBP/ACC pathway but not through PDP1/PDC pathway

• Main Authors: Dongze Li (Author), Na Xu (Author), Yanyan Hou (Author), Wenjing Ren (Author), Na Zhang (Author), Xi Wang (Author), Yeying Sun (Author), Wenxue Lu (Author), Guiwu Qu (Author), Yan Yu (Author), Changjun Lv (Author), Fang Han (Author)
• Format: Book
• Published: BMC, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The mechanisms of chronic intermittent hypoxia (CIH)-induced cognitive deficits remain unclear. Here, our study found that about 3 months CIH treatment induced lipid droplets (LDs) accumulation in hippocampal nerve and glia cells of C57BL/6 mice, and caused severe neuro damage including neu...