Discovery of pyrimidine-tethered benzothiazole derivatives as novel anti-tubercular agents towards multi- and extensively drug resistant Mycobacterium tuberculosis

• Main Authors: Loah R. Hemeda (Author), Mahmoud A. El Hassab (Author), Mohamed A. Abdelgawad (Author), Eman F. Khaleel (Author), Marwa M. Abdel-Aziz (Author), Faizah A. Binjubair (Author), Sara T. Al-Rashood (Author), Wagdy M. Eldehna (Author), Mohamed K. El-Ashrey (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this study, new benzothiazole-pyrimidine hybrids (5a-c, 6, 7a-f, and 8-15) were designed and synthesised. Two different functionalities on the pyrimidine moiety of lead compound 4 were subjected to a variety of chemical changes with the goal of creating various functionalities and cyclisation to...