Catalytic cleavage activities of 10-23 DNAzyme analogs functionalized with an amino group in its catalytic core

• Egile Nagusiak: Qi Wang (Egilea), Di Zhang (Egilea), Maosheng Cheng (Egilea), Junlin He (Egilea), Keliang Liu (Egilea)
• Formatua: Liburua
• Argitaratua: Elsevier, 2012-02-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Functionalization of the catalytic loop of 10-23 DNAzyme with an amino group was performed by incorporation of 7-(3-aminopropyl)-8-aza-7-deaza-2'-deoxyadenosine in different single positions. Among the nine modified positions in the catalytic loop, A9 is the unique position with positive contri...