Catalytic cleavage activities of 10-23 DNAzyme analogs functionalized with an amino group in its catalytic core

• Main Authors: Qi Wang (Author), Di Zhang (Author), Maosheng Cheng (Author), Junlin He (Author), Keliang Liu (Author)
• Format: Book
• Published: Elsevier, 2012-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Functionalization of the catalytic loop of 10-23 DNAzyme with an amino group was performed by incorporation of 7-(3-aminopropyl)-8-aza-7-deaza-2'-deoxyadenosine in different single positions. Among the nine modified positions in the catalytic loop, A9 is the unique position with positive contri...