Natural helix 9 mutants of PPARγ differently affect its transcriptional activity

• Main Authors: Marjoleine F. Broekema (Author), Maarten P.G. Massink (Author), Cinzia Donato (Author), Joep de Ligt (Author), Joerg Schaarschmidt (Author), Anouska Borgman (Author), Marieke G. Schooneman (Author), Diana Melchers (Author), Martin N. Gerding (Author), René Houtman (Author), Alexandre M.J.J. Bonvin (Author), Amit R. Majithia (Author), Houshang Monajemi (Author), Gijs W. van Haaften (Author), Maarten R. Soeters (Author), Eric Kalkhoven (Author)
• Format: Book
• Published: Elsevier, 2019-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: The nuclear receptor PPARγ is the master regulator of adipocyte differentiation, distribution, and function. In addition, PPARγ induces terminal differentiation of several epithelial cell lineages, including colon epithelia. Loss-of-function mutations in PPARG result in familial partial l...