HDAC2 and HDAC5 Up-Regulations Modulate Survivin and miR-125a-5p Expressions and Promote Hormone Therapy Resistance in Estrogen Receptor Positive Breast Cancer Cells

• Main Authors: Wen-Tsung Huang (Author), Yu-Hsuan Tsai (Author), Shang-Hung Chen (Author), Ching-Wen Kuo (Author), Yao-Lung Kuo (Author), Kuo-Ting Lee (Author), Wen-Chung Chen (Author), Pei Chih Wu (Author), Chun-Yu Chuang (Author), Siao Muk Cheng (Author), Chun-Hui Lin (Author), Euphemia Yee Leung (Author), Yung-Chieh Chang (Author), Chun Hei Antonio Cheung (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Intrinsic or acquired resistance to hormone therapy is frequently reported in estrogen receptor positive (ER+) breast cancer patients. Even though dysregulations of histone deacetylases (HDACs) are known to promote cancer cells survival, the role of different HDACs in the induction of hormone therap...