Differential Effect of Schisandrin B Stereoisomers on ATR-Mediated DNA Damage Checkpoint Signaling

• প্রধান লেখক: Naoto Tatewaki (লেখক), Hiroshi Nishida (লেখক), Masaaki Yoshida (লেখক), Hidehiro Ando (লেখক), Seizo Kondo (লেখক), Toshiyuki Sakamaki (লেখক), Tetsuya Konishi (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Elsevier, 2013-01-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

We have previously reported that schisandrin B (SchB) is a specific inhibitor of ATR (ataxia telangiectasia and Rad-3-related) protein kinase. Since SchB consists of a mixture of its diastereomers gomisin N (GN) and γ-schisandrin (γ-Sch), the inhibitory action of SchB might result from a stereospeci...