Differential Effect of Schisandrin B Stereoisomers on ATR-Mediated DNA Damage Checkpoint Signaling

• Main Authors: Naoto Tatewaki (Author), Hiroshi Nishida (Author), Masaaki Yoshida (Author), Hidehiro Ando (Author), Seizo Kondo (Author), Toshiyuki Sakamaki (Author), Tetsuya Konishi (Author)
• Format: Book
• Published: Elsevier, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We have previously reported that schisandrin B (SchB) is a specific inhibitor of ATR (ataxia telangiectasia and Rad-3-related) protein kinase. Since SchB consists of a mixture of its diastereomers gomisin N (GN) and γ-schisandrin (γ-Sch), the inhibitory action of SchB might result from a stereospeci...