A Novel Selective JAK2 Inhibitor Identified Using Pharmacological Interactions

• Main Authors: Tony Eight Lin (Author), Wei-Chun HuangFu (Author), Min-Wu Chao (Author), Tzu-Ying Sung (Author), Chao-Di Chang (Author), Yi-Ying Chen (Author), Jui-Hua Hsieh (Author), Huang-Ju Tu (Author), Han-Li Huang (Author), Shiow-Lin Pan (Author), Kai-Cheng Hsu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The JAK2/STAT signaling pathway mediates cytokine receptor signals that are involved in cell growth, survival and homeostasis. JAK2 is a member of the Janus kinase (JAK) family and aberrant JAK2/STAT is involved with various diseases, making the pathway a therapeutic target. The similarity between t...