Design and Synthesis of New Pyrimidine-Quinolone Hybrids as Novel <i>h</i>LDHA Inhibitors

• Asıl Yazarlar: Iván Díaz (Yazar), Sofia Salido (Yazar), Manuel Nogueras (Yazar), Justo Cobo (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: MDPI AG, 2022-06-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

A battery of novel pyrimidine-quinolone hybrids was designed by docking scaffold replacement as lactate dehydrogenase A (<i>h</i>LDHA) inhibitors. Structures with different linkers between the pyrimidine and quinolone scaffolds (<b>10</b>-<b>21</b> and <b>24...