Ex Vivo Lung Perfusion with β-Nicotinamide Adenine Dinucleotide (NAD⁺) Improves Ischemic Lung Function

• Main Authors: Jonas Peter Ehrsam (Author), Jin Chen (Author), Hector Rodriguez Cetina Biefer (Author), Isabelle Opitz (Author), Stephan Arni (Author), Ilhan Inci (Author)
• Format: Book
• Published: MDPI AG, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ischemia-reperfusion injury compromises short- and long-term outcomes after lung transplantation. The scarce existing data on NAD⁺ suggest effects on hypoxia-induced vasoconstriction, on reactive oxygen species and on tampering inflammation. We exposed rat lungs to 14 h of col...