Pharmacokinetics, Tolerability, and Safety of Esmethadone in Subjects with Chronic Kidney Disease or Hepatic Impairment

• Main Authors: Nicola Ferri (Author), Sara De Martin (Author), James Stuart (Author), Sergio Traversa (Author), Andrea Mattarei (Author), Stefano Comai (Author), Franco Folli (Author), Marco Pappagallo (Author), Clotilde Guidetti (Author), Charles E. Inturrisi (Author), Paolo L. Manfredi (Author)
• Format: Book
• Published: Adis, Springer Healthcare, 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background and Objectives Esmethadone (dextromethadone; d-methadone; S-methadone (+)-methadone; REL-1017) is a low potency N-methyl-D-aspartate (NMDA) receptor channel blocker that showed a rapid and sustained adjunctive antidepressant effects in patients with major depressive disorder with...