Cell-cycle and apoptosis related and proteomics-based signaling pathways of human hepatoma Huh-7 cells treated by three currently used multi-RTK inhibitors

• Main Authors: Xuejiao Ren (Author), Qingning Zhang (Author), Wenyan Guo (Author), Lan Wang (Author), Tao Wu (Author), Wei Zhang (Author), Ming Liu (Author), Dezhi Kong (Author)
• Format: Bog
• Udgivet: Frontiers Media S.A., 2022-08-01T00:00:00Z.
• Fag: article
• Online adgang: Connect to this object online.

Sorafenib, lenvatinib and regorafenib, the multi-RTK inhibitors with potent anti-angiogenesis effects, are currently therapeutic drugs generally recommended for the patients with advanced hepatocellular carcinoma (HCC). To date, however, there have been no published studies on the mechanism underlin...