Structural analysis of light chain-driven bispecific antibodies targeting CD47 and PD-L1

• Main Authors: Pauline Malinge (Author), Xavier Chauchet (Author), Jérémie Bourguignon (Author), Nicolas Bosson (Author), Sébastien Calloud (Author), Tereza Bautzova (Author), Marie Borlet (Author), Mette Laursen (Author), Vinardas Kelpsas (Author), Nadia Rose (Author), Franck Gueneau (Author), Ulla Ravn (Author), Giovanni Magistrelli (Author), Nicolas Fischer (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In contrast to natural antibodies that rely mainly on the heavy chain to establish contacts with their cognate antigen, we have developed a bispecific antibody format in which the light chain (LC) drives antigen binding and specificity. To better understand epitope-paratope interactions in this cont...