Structural analysis of light chain-driven bispecific antibodies targeting CD47 and PD-L1

• Главные авторы: Pauline Malinge (Автор), Xavier Chauchet (Автор), Jérémie Bourguignon (Автор), Nicolas Bosson (Автор), Sébastien Calloud (Автор), Tereza Bautzova (Автор), Marie Borlet (Автор), Mette Laursen (Автор), Vinardas Kelpsas (Автор), Nadia Rose (Автор), Franck Gueneau (Автор), Ulla Ravn (Автор), Giovanni Magistrelli (Автор), Nicolas Fischer (Автор)
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• Опубликовано: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Предметы: article
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In contrast to natural antibodies that rely mainly on the heavy chain to establish contacts with their cognate antigen, we have developed a bispecific antibody format in which the light chain (LC) drives antigen binding and specificity. To better understand epitope-paratope interactions in this cont...