TJ-M2010-5, a novel CNS drug candidate, attenuates acute cerebral ischemia-reperfusion injury through the MyD88/NF-κB and ERK pathway

• Main Authors: Zeyang Li (Author), Minghui Zhao (Author), Xiaoqian Zhang (Author), Yiran Lu (Author), Yang Yang (Author), Yalong Xie (Author), Zhimiao Zou (Author), Liang Zhou (Author), Runshi Shang (Author), Limin Zhang (Author), Fengchao Jiang (Author), Dunfeng Du (Author), Ping Zhou (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Cerebral ischemia-reperfusion injury (CIRI) inevitably occurs after vascular recanalization treatment for ischemic stroke. The accompanying inflammatory cascades have a major impact on outcome and regeneration after ischemic stroke. Evidences have demonstrated that TLR/MyD88/NF-κB signal...