Imiquimod enhances excitability of dorsal root ganglion neurons by inhibiting background (K_2P) and voltage-gated (K_v1.1 and K_v1.2) potassium channels

• Main Authors: Lee Jaekwang (Author), Kim Taekeun (Author), Hong Jinpyo (Author), Woo Junsung (Author), Min Hyunjung (Author), Hwang Eunmi (Author), Lee Sung (Author), Lee C Justin (Author)
• פורמט: ספר
• יצא לאור: SAGE Publishing, 2012-01-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Imiquimod (IQ) is known as an agonist of Toll-like receptor 7 (TLR7) and is widely used to treat various infectious skin diseases. However, it causes severe itching sensation as its side effect. The precise mechanism of how IQ causes...