Novel Dual Acetyl- and Butyrylcholinesterase Inhibitors Based on the Pyridyl-Pyridazine Moiety for the Potential Treatment of Alzheimer's Disease

• Main Authors: Mohamed Elsawalhy (Author), Adel A-H (Author), Ebtesam A. Basiony (Author), Salma A. Ellithy (Author), Allam A. Hassan (Author), Eman S. Abou-Amra (Author), Abdelhamid Ismail (Author), Abdulrahman A. Almehizia (Author), Mohamed A. Al-Omar (Author), Ahmed M. Naglah (Author), Nasser A. Hassan (Author)
• פורמט: ספר
• יצא לאור: MDPI AG, 2024-10-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

<b>Background</b>: Alzheimer's disease (AD) is characterized by cholinergic dysfunction, making the inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) critical for improving cholinergic neurotransmission. However, the development of effective dual inhibitors...