The functionality of a therapeutic antibody candidate restored by a single mutation from proline to threonine in the variable region

• Main Authors: Marie Hautiere (Author), Irene Maffucci (Author), Narciso Costa (Author), Amaury Herbet (Author), Sosthene Essono (Author), Séverine Padiolleau-Lefevre (Author), Didier Boquet (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACTmAbs play an essential role in the therapeutic arsenal. Our laboratory has patented the Rendomab-B49 mAb targeting the endothelin B receptor (ETB). This G protein-coupled receptor plays a driving role in the progression of numerous cancers. We chimerized our mAb (xiRB49) to evaluate its prec...