Extracellular lipidome change by an SGLT2 inhibitor, luseogliflozin, contributes to prevent skeletal muscle atrophy in db/db mice

• Main Authors: Ryo Bamba (Author), Takuro Okamura (Author), Yoshitaka Hashimoto (Author), Saori Majima (Author), Takafumi Senmaru (Author), Emi Ushigome (Author), Naoko Nakanishi (Author), Mai Asano (Author), Masahiro Yamazaki (Author), Hiroshi Takakuwa (Author), Masahide Hamaguchi (Author), Michiaki Fukui (Author)
• Format: Book
• Published: Wiley, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Diabetes mellitus increases the excretion of urinary glucose from the renal glomeruli due to elevated blood glucose levels. In the renal tubules, SGLT2 is expressed and reabsorbs the excreted urinary glucose. In the pathogenesis of diabetes mellitus, glucose reabsorption by SGLT2...