The arginine sensing and transport binding sites are distinct in the human pathogen Leishmania.

• Main Authors: Harsh Pawar (Author), Madhu Puri (Author), Renana Fischer Weinberger (Author), Rentala Madhubala (Author), Dan Zilberstein (Author)
• Format: Knjiga
• Izdano: Public Library of Science (PLoS), 2019-04-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

The intracellular protozoan parasite Leishmania donovani causes human visceral leishmaniasis. Intracellular L. donovani that proliferate inside macrophage phagolysosomes compete with the host for arginine, creating a situation that endangers parasite survival. Parasites have a sensor that upon argin...