Solubility and Physical Stability Enhancement of Loratadine by Preparation of Co-Amorphous Solid Dispersion with Chlorpheniramine and Polyvinylpyrrolidone

• मुख्य लेखकों: Krit Suknuntha (लेखक), Nattakanwadee Khumpirapang (लेखक), Vimon Tantishaiyakul (लेखक), Siriporn Okonogi (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2023-10-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Loratadine (LRD), a non-sedating and slow-acting antihistamine, is often given in combination with short-onset chlorpheniramine maleate (CPM) to increase efficacy. However, LRD has poor water solubility resulting in low bioavailability. The aim of this study was to improve LRD solubility by preparin...