Hyaluronic Acid-Conjugated PLGA Nanoparticles Alleviate Ulcerative Colitis via CD44-Mediated Dual Targeting to Inflamed Colitis Tissue and Macrophages

• Main Authors: Shwe Phyu Hlaing (Author), Jiafu Cao (Author), Juho Lee (Author), Jihyun Kim (Author), Aruzhan Saparbayeva (Author), Dongmin Kwak (Author), Hyunwoo Kim (Author), Seonghwan Hwang (Author), Hwayoung Yun (Author), Hyung Ryong Moon (Author), Yunjin Jung (Author), Jin-Wook Yoo (Author)
• Format: Book
• Published: MDPI AG, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Although various local anti-inflammatory therapies for ulcerative colitis have been developed, rapid drug elimination from inflamed colitis tissue and off-target side effects reduce their therapeutic efficacy. In this study, we synthesized curcumin (Cur)-loaded hyaluronic acid (HA)-conjugated nanopa...