Off-target binding of an anti-amyloid beta monoclonal antibody to platelet factor 4 causes acute and chronic toxicity in cynomolgus monkeys

• Main Authors: Lise I. Loberg (Author), Meha Chhaya (Author), Alexander Ibraghimov (Author), Edit Tarcsa (Author), Andreas Striebinger (Author), Andreas Popp (Author), Lili Huang (Author), Frank Oellien (Author), Stefan Barghorn (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABT-736 is a humanized monoclonal antibody generated to target a specific conformation of the amyloid-beta (Aβ) protein oligomer. Development of ABT-736 for Alzheimer's disease was discontinued due to severe adverse effects (AEs) observed in cynomolgus monkey toxicity studies. The acute nature...