Pharmacokinetics, distribution, and excretion of sodium oligomannate, a recently approved anti-Alzheimer's disease drug in China

• Main Authors: Jiaojiao Lu (Author), Qiongqun Pan (Author), Jieqiang Zhou (Author), Yan Weng (Author), Kaili Chen (Author), Lv Shi (Author), Guanxiu Zhu (Author), Chunlin Chen (Author), Liang Li (Author), Meiyu Geng (Author), Zhenqing Zhang (Author)
• Format: Book
• Published: Elsevier, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The National Medical Products Administration has authorized sodium oligomannate for treating mild-to-moderate Alzheimer's disease. In this study, an LC-MS/MS method was developed and validated to quantitate sodium oligomannate in different biomatrices. The plasma pharmacokinetics, tissue distri...