Signal Transducer and Activator of Transcription 3 (STAT3) Suppresses STAT1/Interferon Signaling Pathway and Inflammation in Senescent Preadipocytes

• Main Authors: Aisha Y. Madani (Author), Yasser Majeed (Author), Houari B. Abdesselem (Author), Maha V. Agha (Author), Muneera Vakayil (Author), Nour K. Al Sukhun (Author), Najeeb M. Halabi (Author), Pankaj Kumar (Author), Shahina Hayat (Author), Mohamed A. Elrayess (Author), Arash Rafii (Author), Karsten Suhre (Author), Nayef A. Mazloum (Author)
• Format: Book
• Published: MDPI AG, 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Obesity promotes premature aging and dysfunction of white adipose tissue (WAT) through the accumulation of cellular senescence. The senescent cells burden in WAT has been linked to inflammation, insulin-resistance (IR), and type 2 diabetes (T2D). There is limited knowledge about molecular mechanisms...