Therapeutic blockade of CXCR2 rapidly clears inflammation in arthritis and atopic dermatitis models: demonstration with surrogate and humanized antibodies

• Main Authors: Md Jahangir Alam (Author), Liang Xie (Author), Caroline Ang (Author), Farnaz Fahimi (Author), Stephen B. Willingham (Author), Andrew J. Kueh (Author), Marco J. Herold (Author), Charles R. Mackay (Author), Remy Robert (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Neutrophils are the most abundant effector cells of the innate immune system and represent the first line of defense against infection. However, in many common pathologies, including autoimmune diseases, excessive recruitment and activation of neutrophils can drive a chronic inflammatory response le...