Celecoxib inhibits osteoblast maturation by suppressing the expression of Wnt target genes

• Main Authors: Akihiro Nagano (Author), Masaki Arioka (Author), Fumi Takahashi-Yanaga (Author), Etsuko Matsuzaki (Author), Toshiyuki Sasaguri (Author)
• Format: Book
• Published: Elsevier, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Non-steroidal anti-inflammatory drugs (NSAIDs) have been shown to impair bone healing. We previously reported that in colon cancer cells, celecoxib, a COX-2-selective NSAID, inhibited the canonical Wnt/β-catenin signaling pathway. Since this pathway also plays an important role in osteoblast growth...