Axon degeneration and PGC-1α-mediated protection in a zebrafish model of α-synuclein toxicity

• Autori principali: Kelley C. O'Donnell (Autore), Aaron Lulla (Autore), Mark C. Stahl (Autore), Nickolas D. Wheat (Autore), Jeff M. Bronstein (Autore), Alvaro Sagasti (Autore)
• Natura: Libro
• Pubblicazione: The Company of Biologists, 2014-05-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

α-synuclein (aSyn) expression is implicated in neurodegenerative processes, including Parkinson's disease (PD) and dementia with Lewy bodies (DLB). In animal models of these diseases, axon pathology often precedes cell death, raising the question of whether aSyn has compartment-specific toxic e...