Axon degeneration and PGC-1α-mediated protection in a zebrafish model of α-synuclein toxicity

Axon degeneration and PGC-1α-mediated protection in a zebrafish model of α-synuclein toxicity

α-synuclein (aSyn) expression is implicated in neurodegenerative processes, including Parkinson's disease (PD) and dementia with Lewy bodies (DLB). In animal models of these diseases, axon pathology often precedes cell death, raising the question of whether aSyn has compartment-specific toxic e...

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Main Authors: Kelley C. O'Donnell (Author), Aaron Lulla (Author), Mark C. Stahl (Author), Nickolas D. Wheat (Author), Jeff M. Bronstein (Author), Alvaro Sagasti (Author)
Format: Book
Published: The Company of Biologists, 2014-05-01T00:00:00Z.
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