Axon degeneration and PGC-1α-mediated protection in a zebrafish model of α-synuclein toxicity

• Main Authors: Kelley C. O'Donnell (Author), Aaron Lulla (Author), Mark C. Stahl (Author), Nickolas D. Wheat (Author), Jeff M. Bronstein (Author), Alvaro Sagasti (Author)
• Format: Book
• Published: The Company of Biologists, 2014-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

α-synuclein (aSyn) expression is implicated in neurodegenerative processes, including Parkinson's disease (PD) and dementia with Lewy bodies (DLB). In animal models of these diseases, axon pathology often precedes cell death, raising the question of whether aSyn has compartment-specific toxic e...