Axon degeneration and PGC-1α-mediated protection in a zebrafish model of α-synuclein toxicity

• Главные авторы: Kelley C. O'Donnell (Автор), Aaron Lulla (Автор), Mark C. Stahl (Автор), Nickolas D. Wheat (Автор), Jeff M. Bronstein (Автор), Alvaro Sagasti (Автор)
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• Опубликовано: The Company of Biologists, 2014-05-01T00:00:00Z.
• Предметы: article
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α-synuclein (aSyn) expression is implicated in neurodegenerative processes, including Parkinson's disease (PD) and dementia with Lewy bodies (DLB). In animal models of these diseases, axon pathology often precedes cell death, raising the question of whether aSyn has compartment-specific toxic e...