Cinobufagin induces acute promyelocytic leukaemia cell apoptosis and PML-RARA degradation in a caspase-dependent manner by inhibiting the β-catenin signalling pathway

• Main Authors: Yaoyao Bian (Author), Mei Xue (Author), Xinlong Guo (Author), Wenjuan Jiang (Author), Ye Zhao (Author), Zhaofeng Zhang (Author), Xian Wang (Author), Yongkang Hu (Author), Qi Zhang (Author), Wenliang Dun (Author), Liang Zhang (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Context Acute promyelocytic leukaemia (APL) is a malignant hematological tumour characterized by the presence of promyelocytic leukaemia-retinoic acid receptor A (PML-RARA) fusion protein. Cinobufagin (CBG) is one of the main effective components of toad venom with antitumor properties. However, onl...