Structural and In Vitro Functional Comparability Analysis of Altebrel™, a Proposed Etanercept Biosimilar: Focus on Primary Sequence and Glycosylation

• Main Authors: Ramin Fazel (Author), Yudong Guan (Author), Behrouz Vaziri (Author), Christoph Krisp (Author), Laura Heikaus (Author), Amirhossein Saadati (Author), Siti Nurul Hidayah (Author), Manasi Gaikwad (Author), Hartmut Schlüter (Author)
• Format: Book
• Published: MDPI AG, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The demand for reliable comparability studies of biosimilars grows with their increased market share. These studies focus on physicochemical, structural, functional and clinical properties to ensure that a biosimilar has no significant differences to the originator product and can be released into t...