Preclinical anti‐angiogenic and anti‐cancer activities of BAY1143269 in glioblastoma via targeting oncogenic protein expression

• Autori principali: Weifeng Wan (Autore), Xin Zhang (Autore), Changren Huang (Autore), Ligang Chen (Autore), Xiaobo Yang (Autore), Kunyang Bao (Autore), Tangming Peng (Autore)
• Natura: Libro
• Pubblicazione: Wiley, 2022-08-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Abstract Glioblastoma angiogenesis is critical for tumor growth, making it an appealing target for treatment development. BAY1143269 is a novel inhibitor of mitogen‐activated protein kinase interacting serine/threonine‐protein kinase 1 (MKN1) and has potent anti‐cancer activity. We identified BAY114...