Pharmacogenetic variants of CYP2C9 and CYP2C19 associated with adverse reactions induced by antiepileptic drugs used in Peru

• Main Authors: Angel T. Alvarado (Author), Ana María Muñoz (Author), Nelson Varela (Author), Luis Sullón-Dextre (Author), Mario Pineda (Author), Mario Bolarte-Arteaga (Author), María R. Bendezú (Author), Jorge A. García (Author), Haydee Chávez (Author), Felipe Surco-Laos (Author), Elizabeth J. Melgar-Merino (Author), Pompeyo A. Cuba-Garcia (Author), Aura Molina-Cabrera (Author), Bertha Pari-Olarte (Author), Mario Bonifaz-Hernandez (Author), Juan F. Panay-Centeno (Author), José Kong-Chirinos (Author), José Almeida-Galindo (Author)
• Format: Book
• Published: Pensoft Publishers, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Epilepsy is the most common neurological disorder with a worldwide incidence of 20% and a treatment failure rate of 25-30%. The fluctuation in serum levels, efficacy and safety of antiepileptic drugs can be attributed to single nucleotide polymorphisms of genes encoding their respective proteins inv...